A 61-year-old man with a history of hypertension and chronic kidney disease (stage 3b) presents to the emergency department with acute-onset left facial droop, left arm weakness, and dysarthria. The symptoms began 2.5 hours ago. Vital signs are BP 168/94 mmHg, HR 88 bpm, RR 16, temperature 37.2°C, and SpO2 98% on room air. Non-contrast head CT and CT angiography show no evidence of acute ischemia or hemorrhage. The patient receives intravenous alteplase 0.9 mg/kg (maximum dose) within the therapeutic window. Four hours after thrombolysis, the patient develops severe occipital headache and progressive altered mental status. Repeat non-contrast head CT demonstrates a hyperdense signal in the territory of the right middle cerebral artery with mild mass effect. Which of the following complications has most likely occurred?
- A)Reocclusion of the middle cerebral artery from rethrombosis despite thrombolysis
- B)Hemorrhagic transformation of the acute ischemic infarctionGABARITO
- C)Acute hypertensive emergency secondary to pain and anxiety from thrombolysis
- D)Subarachnoid hemorrhage from rupture of an undiagnosed aneurysm
- E)Subdural hematoma from a fall during acute stroke symptoms
Explicação
Hemorrhagic transformation (HT) is a known complication of thrombolytic therapy for acute ischemic stroke, occurring in approximately 5-10% of patients receiving IV alteplase. The clinical scenario is classic: initial ischemic stroke without hemorrhage on imag... Ver explicação completa e trilha adaptativa →