A 61-year-old man with a history of hypertension and chronic kidney disease (stage 3b) presents to the emergency department with acute-onset left facial droop, left arm weakness, and dysarthria. The symptoms began 2.5 hours ago. Vital signs are BP 168/94 mmHg, HR 88 bpm, RR 16, temperature 37.2°C, and SpO2 98% on room air. Non-contrast head CT and CT angiography show no evidence of acute ischemia or hemorrhage. The patient receives intravenous alteplase 0.9 mg/kg (maximum dose) within the therapeutic window. Four hours after thrombolysis, the patient develops severe occipital headache and progressive altered mental status. Repeat non-contrast head CT demonstrates a hyperdense signal in the territory of the right middle cerebral artery with mild mass effect. Which of the following complications has most likely occurred?

  1. A)Reocclusion of the middle cerebral artery from rethrombosis despite thrombolysis
  2. B)Hemorrhagic transformation of the acute ischemic infarctionGABARITO
  3. C)Acute hypertensive emergency secondary to pain and anxiety from thrombolysis
  4. D)Subarachnoid hemorrhage from rupture of an undiagnosed aneurysm
  5. E)Subdural hematoma from a fall during acute stroke symptoms

Explicação

Hemorrhagic transformation (HT) is a known complication of thrombolytic therapy for acute ischemic stroke, occurring in approximately 5-10% of patients receiving IV alteplase. The clinical scenario is classic: initial ischemic stroke without hemorrhage on imag... Ver explicação completa e trilha adaptativa →

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