A 55-year-old woman with type 2 diabetes mellitus presents with fatigue and polyuria. Vital signs show BP 138/82 mmHg, HR 88/min, RR 16/min, temperature 37°C, SpO2 98% on room air. Recent fasting glucose is 186 mg/dL; HbA1c is 8.2%. She denies chest pain or dyspnea. Her physician initiates an oral antidiabetic agent that increases endogenous insulin secretion by closing ATP-sensitive potassium channels in pancreatic beta cells. Which drug works by this mechanism?
- A)Pioglitazone
- B)Metformin
- C)Empagliflozin
- D)Acarbose
- E)GlyburideGABARITO
Explicação
Glyburide is a sulfonylurea that closes ATP sensitive potassium channels in pancreatic beta cells, causing depolarization, calcium influx, and insulin release. This mechanism directly increases endogenous insulin secretion and therefore can cause hypoglycemia. Ver explicação completa e trilha adaptativa →