A 38-year-old man presents for lipid screening with BP 138/88, HR 82, RR 16, temp 37°C, SpO2 98%. Lipid panel reveals LDL cholesterol 240 mg/dL, triglycerides 350 mg/dL, and HDL cholesterol 35 mg/dL. Apolipoprotein E genotyping demonstrates E2/E3 phenotype. Family history is significant for early coronary artery disease. He denies current statin use. Which lipoprotein would be expected to be most elevated?
- A)HDL particles
- B)Chylomicron remnantsGABARITO
- C)VLDL remnants only
- D)Small dense LDL particles
- E)Lipoprotein(a)
Explicação
ApoE2/E3 phenotype, particularly with homozygous E2/E2, causes Type III hyperlipoproteinemia (familial dysbetalipoproteinemia). ApoE2 has reduced binding affinity for the LDL receptor and apoE2 receptor, impairing clearance of chylomicron remnants and VLDL rem... Ver explicação completa e trilha adaptativa →