A 57-year-old woman with symptomatic primary hyperparathyroidism presents with muscle weakness and cognitive changes. Vital signs: BP 138/88, HR 92, RR 16, Temp 37°C. Labs show serum calcium 11.8 mg/dL and alkaline phosphatase 78 U/L. Imaging confirms a solitary left parathyroid adenoma. She denies recent diuretic use. Surgical removal is planned. Which of the following laboratory values would most likely have been elevated preoperatively?
- A)Urinary cyclic AMPGABARITO
- B)Serum calcitonin
- C)Urinary metanephrines
- D)Serum phosphate
- E)Plasma renin activity
Explicação
PTH stimulates adenylate cyclase in the kidney, so urinary cyclic AMP is increased in primary hyperparathyroidism. The disorder also causes hypercalcemia and renal phosphate wasting. This physiologic effect reflects normal PTH signaling at the renal tubule. Ver explicação completa e trilha adaptativa →