A 63 year old man undergoes colonoscopy after a positive stool DNA screening test. A 2.5 cm pedunculated adenoma is removed from the sigmoid colon. Molecular analysis of the adenoma demonstrates a mutation that promotes constitutive signaling through a GTP binding protein and drives progression from early to intermediate adenoma. Which gene is most likely mutated?
- A)RET
- B)WT1
- C)APC
- D)KRASGABARITO
- E)RB
Explicação
In the classic adenoma carcinoma sequence of sporadic colorectal cancer, APC loss is an early event and KRAS activation commonly promotes progression from a small adenoma to a larger, more dysplastic lesion. KRAS encodes a GTP binding signaling protein that be... Ver explicação completa e trilha adaptativa →