A 61-year-old man with a 50 pack year smoking history presents with severe proximal muscle weakness, hypertension, edema, and new hyperglycemia. He has marked hypokalemic metabolic alkalosis. Testing confirms hypercortisolism with elevated ACTH. High dose dexamethasone fails to suppress cortisol production. Which of the following is the most likely source of his endocrine abnormality?
- A)Primary hyperaldosteronism
- B)Pituitary corticotroph adenoma
- C)Small cell carcinoma of the lungGABARITO
- D)Adrenal cortical adenoma
- E)Hashimoto thyroiditis
Explicação
Ectopic ACTH production classically occurs in small cell lung carcinoma and causes severe hypercortisolism with marked hypokalemic metabolic alkalosis. Ver explicação completa e trilha adaptativa →