A 48-year-old man with resistant hypertension (BP 168/104 mmHg) and hypokalemia (K+ 3.2 mEq/L) is diagnosed with primary hyperaldosteronism from an adrenal adenoma on CT imaging. While awaiting surgical resection, he is started on medical therapy. Two months later, he develops tender gynecomastia and reports decreased libido. He denies chest pain or dyspnea. Which medication most likely caused these adverse effects?
- A)Furosemide
- B)SpironolactoneGABARITO
- C)Amiloride
- D)Mannitol
- E)Hydrochlorothiazide
Explicação
Spironolactone antagonizes aldosterone receptors in the collecting duct and is useful in hyperaldosteronism and heart failure. Because it also blocks androgen receptors and increases steroid hormone imbalance, gynecomastia is a classic adverse effect. Ver explicação completa e trilha adaptativa →