A 22-year-old woman presents with recurrent shoulder and knee dislocations. Vital signs: BP 118/76, HR 88, RR 16, Temp 37°C, SpO2 98%. Physical examination reveals hyperextensible skin, hypermobile fingers, and poor wound healing with keloid formation. Labs show normal platelet count. She reports minor cuts heal with abnormal scarring and poor tensile strength. She denies recent infections or autoimmune disease. Which mechanism best explains her impaired wound healing?
- A)Defect in copper dependent lysyl oxidase
- B)Defect in type I collagen synthesis
- C)Defect in collagen processing causing hyperextensible skin and poor wound healingGABARITO
- D)Defect in dystrophin
- E)Defect in fibrillin
Explicação
Ehlers Danlos syndromes are caused by defects in collagen synthesis or processing, producing weak connective tissue. Hyperextensible skin, joint hypermobility, and poor wound healing with tissue fragility are classic findings. Ver explicação completa e trilha adaptativa →