A 21-year-old male participates in a nutrition study. Two hours after consuming a high-carbohydrate meal, he has elevated serum insulin levels (18 mIU/L; normal fasting <12). Vital signs are normal: BP 118/76, HR 82, RR 16, Temp 98.6°F, SpO2 99%. Blood glucose is 145 mg/dL. He denies medication use and has no family history of diabetes. Which of the following changes is most likely occurring in his hepatocytes at this time?
- A)Activation of hormone sensitive lipase increases lipolysis
- B)Increased glucagon promotes ketogenesis
- C)Decreased fatty acid synthase activity reduces triglyceride synthesis
- D)Decreased acetyl CoA carboxylase activity increases beta oxidation
- E)Increased malonyl CoA inhibits carnitine palmitoyltransferase IGABARITO
Explicação
In the fed state, insulin activates acetyl CoA carboxylase, increasing malonyl CoA production. Malonyl CoA inhibits carnitine palmitoyltransferase I, preventing transport of long chain fatty acids into mitochondria for beta oxidation while favoring fatty acid ... Ver explicação completa e trilha adaptativa →