A full-term male newborn presents with abdominal distention, bilious emesis, and failure to pass meconium by 48 hours of life. Vital signs show HR 145/min, RR 42/min, BP 65/40 mmHg, and temperature 37.2°C. Abdominal X-ray reveals a transition zone with proximal bowel dilation. Rectal examination causes explosive stool release. Notably, there is no intestinal perforation. Rectal suction biopsy is most likely to show which of the following histologic finding?
- A)Absence of ganglion cells in the submucosal and myenteric plexusesGABARITO
- B)Ectopic pancreatic tissue in an ileal diverticulum
- C)Hypertrophy of the circular muscle layer of the pylorus
- D)Transmural granulomatous inflammation
- E)Mucosal pseudopolyps limited to the rectum
Explicação
Hirschsprung disease is caused by failure of neural crest cell migration, producing aganglionosis of the distal colon with functional obstruction. Delayed passage of meconium, abdominal distention, and explosive stool after rectal examination are classic clues... Ver explicação completa e trilha adaptativa →