A 3-day-old male born at term presents with cyanosis. Physical examination reveals differential cyanosis, with the face and upper extremities appearing less blue than the lower body and feet. Vital signs include heart rate 158/min, respiratory rate 50/min, blood pressure 62/38 mmHg, and oxygen saturation 91% in the right hand versus 84% in the left foot. A continuous murmur is audible at the left infraclavicular region. Chest X-ray shows normal pulmonary vascular markings without cardiomegaly. Echocardiography demonstrates right-to-left shunting through a patent ductus arteriosus with elevated pulmonary artery pressures exceeding systemic pressures. The infant has not received prostaglandin E1. Which of the following is the most likely diagnosis?
- A)Transposition of the great arteries with intact ventricular septum
- B)Tetralogy of Fallot with severe right ventricular outflow tract obstruction
- C)Persistent pulmonary hypertension of the newbornGABARITO
- D)Total anomalous pulmonary venous return with restrictive atrial septal defect
- E)Patent ductus arteriosus with left-to-right shunting and pulmonary edema
Explicação
Persistent pulmonary hypertension of the newborn (PPHN) is characterized by suprasystemic pulmonary vascular resistance that causes right-to-left shunting through fetal channels (PDA, foramen ovale, or both). The differential cyanosis (upper body less cyanotic... Ver explicação completa e trilha adaptativa →