A 63 year old man with a 50 pack year smoking history presents with progressive difficulty rising from a chair. He reports dry mouth and erectile dysfunction. Examination shows proximal leg weakness and diminished reflexes that improve after repeated muscle contraction. Chest imaging reveals a hilar mass. Which of the following antibodies is most likely present?
- A)Anti voltage gated potassium channel antibodies
- B)Anti acetylcholine receptor antibodies
- C)Anti aquaporin 4 antibodies
- D)Anti topoisomerase I antibodies
- E)Anti P Q type voltage gated calcium channel antibodiesGABARITO
Explicação
Anti P Q type voltage gated calcium channel antibodies is correct. Lambert Eaton myasthenic syndrome is a paraneoplastic disorder, classically associated with small cell lung carcinoma, that impairs presynaptic calcium dependent acetylcholine release. Proximal... Ver explicação completa e trilha adaptativa →