A 7 year old boy is diagnosed with acute lymphoblastic leukemia, and investigators design a case control study to evaluate household benzene exposure. They match each case to controls from the same home address and same school classroom. The final study finds no association. Which design problem most likely reduced the ability to detect a true exposure effect?
- A)Berkson bias
- B)OvermatchingGABARITO
- C)Immortal time bias
- D)Publication bias
- E)Lead time bias
Explicação
Overmatching occurs when controls are matched on variables closely related to the exposure of interest, which removes real exposure differences between cases and controls. Matching on home address would make benzene exposure very similar in cases and controls,... Ver explicação completa e trilha adaptativa →