A 32-year-old man with a history of multiple endocrine neoplasia type 1 (MEN-1) presents to the emergency department with a 2-month history of episodic severe headaches, profuse diaphoresis, and palpitations. Episodes occur unpredictably, 2-3 times weekly, and last 15-30 minutes. Vital signs show BP 178/108 mmHg, HR 116/min, RR 16/min, temperature 37.1°C. Physical examination reveals no orthostatic hypotension or focal neurologic deficits. A 24-hour urine collection shows elevated metanephrines at 420 nmol/24h (normal <100 nmol/24h). The patient has not taken any sympathomimetic medications or decongestants. Which of the following is the most appropriate next diagnostic step?
- A)Initiate phentolamine infusion during an acute hypertensive episode to confirm diagnosis
- B)Perform high-resolution CT imaging of the adrenal glands and abdomen
- C)Measure plasma free metanephrines after 30 minutes of supine rest in a quiet roomGABARITO
- D)Proceed directly to surgical consultation for adrenalectomy based on biochemical confirmation
- E)Obtain a clonidine suppression test to differentiate pheochromocytoma from essential hypertension
Explicação
Plasma free metanephrines measured after 30 minutes of supine rest in a quiet environment is the most appropriate confirmatory test for suspected pheochromocytoma. This test has superior sensitivity (96-99%) and specificity compared to 24-hour urine metanephri... Ver explicação completa e trilha adaptativa →