A 40-year-old man with a BMI of 31 kg/m² presents for hypertension screening. He has no significant past medical history and takes no medications. Vital signs are normal. Laboratory evaluation reveals: total cholesterol 275 mg/dL, LDL-cholesterol 200 mg/dL, HDL-cholesterol 35 mg/dL, and triglycerides 200 mg/dL. After lifestyle modification counseling, he is started on a bile acid sequestrant for LDL reduction. Which of the following lipid panels would you most likely expect after 6-8 weeks of therapy?
- A)LDL 150 mg/dL, HDL 32 mg/dL, Triglycerides 240 mg/dL
- B)LDL 90 mg/dL, HDL 40 mg/dL, Triglycerides 145 mg/dL
- C)LDL 135 mg/dL, HDL 38 mg/dL, Triglycerides 220 mg/dL
- D)LDL 160 mg/dL, HDL 45 mg/dL, Triglycerides 165 mg/dL
- E)LDL 130 mg/dL, HDL 36 mg/dL, Triglycerides 210 mg/dLGABARITO
Explicação
Bile acid sequestrants (cholestyramine, colestipol, colesevelam) bind bile acids in the intestine, preventing their reabsorption. This increases fecal loss of bile acids and upregulates hepatic LDL receptors, reducing LDL-cholesterol by 15-30%. However, seques... Ver explicação completa e trilha adaptativa →