A 34-year-old man with a history of recurrent acute pancreatitis presents with triglycerides of 450 mg/dL and total cholesterol of 280 mg/dL. His LDL is 140 mg/dL and HDL is 25 mg/dL. He has corneal opacities and eruptive xanthomas. Genetic testing reveals a mutation in the apolipoprotein C-II gene. Which lipoprotein metabolism step is impaired?
- A)Hepatic synthesis of apolipoprotein B-100
- B)Hepatic uptake of remnant particles via LDL receptor
- C)Activation of lipoprotein lipase by its cofactor apolipoprotein C-IIGABARITO
- D)Hydrolysis of hepatic lipase on IDL particles
- E)Esterification of free cholesterol by LCAT
Explicação
Apolipoprotein C-II deficiency (Type V hyperlipoproteinemia) impairs the activation of lipoprotein lipase. ApoC-II is a critical cofactor required for LPL function in hydrolyzing triglycerides in chylomicrons and VLDL at the capillary endothelium. Without adeq... Ver explicação completa e trilha adaptativa →