A full-term newborn presents on day 1 of life with a weak cry, poor suck, and diffuse hypotonia. Vital signs show HR 145/min, RR 38/min, and normal oxygen saturation. The mother reports a 5-year history of fluctuating ptosis and diplopia that significantly worsened during pregnancy. She denies autoimmune disease but reports improvement with anticholinesterase medications. Serum electrolytes and glucose are normal in the infant. Which diagnosis best explains the clinical presentation?
- A)Botulism
- B)Duchenne muscular dystrophy
- C)Spinal muscular atrophy
- D)Transient neonatal myasthenia gravisGABARITO
- E)Tetanus
Explicação
Maternal acetylcholine receptor antibodies can cross the placenta and transiently impair neuromuscular transmission in the newborn. The resulting neonatal myasthenia causes poor feeding, weak cry, and hypotonia but usually resolves as maternal antibodies disap... Ver explicação completa e trilha adaptativa →