A 38-year-old man with chronic spinal cord injury presents with painful lower extremity spasms and increased muscle tone disrupting sleep. Vital signs: BP 128/82, HR 78, RR 16, temp 37°C. Neurologic exam reveals hyperreflexia and rigidity in bilateral lower extremities; upper extremity strength is normal. Recent MRI confirms remote spinal cord lesion at T10. He denies bowel/bladder dysfunction. A GABA_B receptor agonist acting in the spinal cord is prescribed to reduce spasticity. Which drug was most likely given?
- A)Selegiline
- B)BaclofenGABARITO
- C)Trihexyphenidyl
- D)Ropinirole
- E)Edrophonium
Explicação
Baclofen is a GABA_B receptor agonist that reduces excitatory neurotransmission in the spinal cord and is commonly used for spasticity from spinal cord lesions or multiple sclerosis. Spasticity differs from weakness because tone and reflexes are increased. Ver explicação completa e trilha adaptativa →