A 34-year-old woman presents with a 3-month history of progressive polyarticular joint pain and morning stiffness lasting more than 2 hours. Physical examination reveals symmetric swelling of the hands and wrists. Laboratory studies show ESR 52 mm/hr, CRP 8.2 mg/dL, and negative rheumatoid factor. A synovial biopsy from the wrist is obtained and shows hyperplastic synovial lining with increased macrophages and lymphocytic infiltrate in the sublining layer. Which of the following best describes the thickness of the normal synovial intimal lining layer?
- A)1-2 cell layersGABARITO
- B)3-5 cell layers
- C)8-10 cell layers
- D)15-20 cell layers
- E)25-30 cell layers
Explicação
The normal synovial intimal lining layer consists of 1-2 layers of specialized fibroblasts (synovial cells) and macrophages that form a thin barrier between the joint space and the highly vascular subsynovial connective tissue. This characteristic thin lining ... Ver explicação completa e trilha adaptativa →