A 55-year-old man develops acute coronary syndrome. His lipid panel shows total cholesterol of 220 mg/dL and LDL of 140 mg/dL, both moderate elevations. However, his Lp(a) level is markedly elevated at 120 nmol/L (normal <50). Genetic analysis shows a polymorphism in the LPA gene affecting lipoprotein(a) production. Which of the following best explains his cardiovascular risk despite moderate LDL levels?
- A)Lp(a) carries apoB-100 and LDL-C, increasing atherosclerotic burden independently of LDLGABARITO
- B)Lp(a) directly activates lipoprotein lipase in coronary arteries
- C)Lp(a) deficiency is associated with premature myocardial infarction
- D)Lp(a) competes with HDL for hepatic uptake receptors
- E)Lp(a) inhibits hepatic LDL receptor expression
Explicação
Lipoprotein(a) [Lp(a)] is a lipoprotein particle consisting of an LDL-like core (apoB-100, cholesterol ester, triglyceride) covalently bound to apolipoprotein(a). Elevated Lp(a) is an independent cardiovascular risk factor. Lp(a) promotes atherosclerosis throu... Ver explicação completa e trilha adaptativa →