A 3 year old boy is brought to the emergency department with fever and lethargy. Blood cultures later grow Streptococcus pneumoniae. He has had multiple episodes of invasive pyogenic bacterial infection since infancy, but extensive immunologic evaluation shows normal neutrophil count, normal oxidative burst, and normal immunoglobulin levels. Viral and fungal infections have been uncommon. Defective signaling through which of the following is the most likely cause of this patient's condition?
- A)CD28 on naive T cells
- B)Class I major histocompatibility complex molecules
- C)B cell receptor associated tyrosine kinase
- D)Terminal complement components C5 through C9
- E)Toll like receptors that activate NF kappa BGABARITO
Explicação
MyD88 is an adaptor protein used by most Toll like receptors to trigger NF kappa B mediated innate immune activation. Children with MyD88 pathway deficiency develop recurrent invasive pyogenic bacterial infections, especially early in life, despite relatively ... Ver explicação completa e trilha adaptativa →