A 10-year-old boy presents to the emergency department with a 3-week history of progressive jaw swelling and pain. His mother reports he has had fever (38.2°C) and appears fatigued. On examination, there is a firm, non-tender mass of the left mandible with buccal mucosa involvement. The liver and spleen are not enlarged. Laboratory studies reveal: WBC 8,500/μL, hemoglobin 11.2 g/dL, platelets 180,000/μL, LDH 720 U/L, and uric acid 8.4 mg/dL. A biopsy of the mandibular mass shows medium-sized lymphoid cells with abundant cytoplasm, high mitotic rate, and starry-sky appearance. Cytogenetic analysis demonstrates t(8;14)(q24;q32). Which of the following is the most likely diagnosis?
- A)Diffuse large B-cell lymphoma
- B)Mantle cell lymphoma
- C)Lymphoblastic lymphoma
- D)Hodgkin lymphoma, mixed cellularity type
- E)Burkitt lymphomaGABARITO
Explicação
Burkitt lymphoma is a highly aggressive B-cell non-Hodgkin lymphoma characterized by the t(8;14) translocation involving the c-MYC gene (chromosome 8) and the immunoglobulin heavy chain locus (chromosome 14). Key diagnostic features present in this case includ... Ver explicação completa e trilha adaptativa →