A 22-year-old woman presents with progressive fatigue and episodic muscle weakness. Vital signs: BP 118/76 mmHg, HR 92/min, RR 16/min, temp 37°C. Serum potassium 2.8 mEq/L, magnesium 1.4 mg/dL, pH 7.48 with HCO3− 32 mEq/L. Urinary calcium excretion is low. She denies diarrhea or diuretic use. Which of the following best describes her renal tubular disorder?
- A)Inherited defect of the thiazide sensitive Na Cl cotransporterGABARITO
- B)Aldosterone deficiency due to adrenal destruction
- C)Resistance to antidiuretic hormone in the collecting duct
- D)Loss of the loop Na K 2Cl cotransporter
- E)Constitutive activation of the epithelial sodium channel
Explicação
Gitelman syndrome is an inherited defect of the thiazide sensitive Na Cl cotransporter in the distal convoluted tubule. It resembles chronic thiazide exposure and is distinguished from Bartter syndrome by hypocalciuria and often hypomagnesemia. Ver explicação completa e trilha adaptativa →