A 68-year-old man with a 3-month history of weight loss and anemia presents with colon adenocarcinoma. Vital signs show BP 138/82, HR 92, RR 18, Temp 37.2°C. Laboratory findings reveal hemoglobin 9.2 g/dL and CEA 18 ng/mL. Colonoscopy with biopsy confirms adenocarcinoma. Molecular analysis demonstrates maintained telomere length and escape from replicative senescence. Notably, there is no evidence of p53 mutations. Which enzyme is most likely abnormally upregulated in these malignant cells?

1. A)RNA polymerase II
2. B)DNA polymerase alpha
3. C)Primase
4. D)Topoisomerase I
5. E)TelomeraseGABARITO