A 29 year old woman with sickle cell disease presents with sudden severe fatigue after her child had a viral illness with a slapped cheek rash. Laboratory studies show hemoglobin 5.8 g/dL and an undetectable reticulocyte count, but leukocyte and platelet counts are normal. Which of the following is the most likely cause of this patient's acute worsening?
- A)Iron deficiency due to chronic transfusions
- B)Infection of erythroid precursor cells by parvovirus B19GABARITO
- C)Oxidant injury from sulfa medication use
- D)Splenic sequestration crisis due to enlarging spleen
- E)Autoimmune destruction of all hematopoietic precursors
Explicação
Infection of erythroid precursor cells by parvovirus B19 is correct. Patients with chronic hemolytic disorders rely on brisk erythropoiesis to maintain hemoglobin. Parvovirus can transiently suppress erythroid precursors, causing pure red cell aplasia with sev... Ver explicação completa e trilha adaptativa →