A 34 year old man is brought to the emergency department 8 hours after ingesting windshield washer fluid during a suicide attempt. He complains of blurry vision and abdominal pain. Laboratory studies show an anion gap metabolic acidosis. He is treated with fomepizole. Which of the following changes in the alcohol dehydrogenase reaction is most likely produced by this medication?
- A)Increased Km with unchanged VmaxGABARITO
- B)Decreased Km with unchanged Vmax
- C)Decreased Km with decreased Vmax
- D)Unchanged Km with decreased Vmax
- E)Increased Vmax with unchanged Km
Explicação
Fomepizole is a competitive inhibitor of alcohol dehydrogenase. Competitive inhibitors increase the apparent Km because more substrate is required to reach half maximal velocity, but Vmax is unchanged because sufficiently high substrate concentrations can over... Ver explicação completa e trilha adaptativa →