A 49-year-old man with chronic hepatitis C presents with fragile skin and blistering lesions on the dorsal hands worsening with sun exposure. Vital signs: BP 128/82, HR 88, RR 16, Temp 37.2°C, SpO2 98%. He reports dark urine and reports no abdominal pain or psychiatric symptoms. Laboratory studies show elevated transaminases and urine porphobilinogen level within normal limits. Which enzyme is most likely deficient?
- A)Ferrochelatase
- B)ALA synthase
- C)Protoporphyrinogen oxidase
- D)Uroporphyrinogen decarboxylaseGABARITO
- E)Porphobilinogen deaminase
Explicação
Porphyria cutanea tarda is due to uroporphyrinogen decarboxylase deficiency. It causes chronic photosensitivity with blistering skin lesions and tea colored urine, often in association with liver disease or alcohol use. The absence of neurovisceral symptoms he... Ver explicação completa e trilha adaptativa →