A 17-year-old boy with mild hemophilia A presents for elective dental extraction. His hematologist administers an intranasal medication to increase von Willebrand factor and factor VIII release from endothelial Weibel-Palade bodies prior to the procedure. Vital signs are stable (BP 118/76, HR 82, RR 16, Temp 37°C). Laboratory studies show baseline factor VIII activity at 35% and a prolonged partial thromboplastin time. Physical examination reveals no active bleeding or joint swelling. The patient denies headache or chest pain and takes no home medications. Which drug was most likely administered?
- A)Octreotide
- B)Hydrocortisone
- C)Oxytocin
- D)Tolvaptan
- E)DesmopressinGABARITO
Explicação
Desmopressin is not only an ADH analog for central diabetes insipidus but also increases release of von Willebrand factor and factor VIII. That makes it useful for von Willebrand disease and mild hemophilia A before procedures. Ver explicação completa e trilha adaptativa →