A 3-week-old infant presents with tachypnea, poor feeding, and failure to gain weight. Vital signs show heart rate 165 bpm, respiratory rate 58/min, blood pressure 65/40 mmHg, and oxygen saturation 88% on room air. The infant has no cyanosis at rest. Echocardiography reveals a single arterial trunk arising from the heart, supplying systemic, pulmonary, and coronary circulations. Chest X-ray shows pulmonary edema. Which embryologic defect most likely caused this condition?
- A)Failure of neural crest migration into the aorticopulmonary septumGABARITO
- B)Abnormal left right dynein function
- C)Failure of ductus arteriosus to close
- D)Failure of endocardial cushion fusion
- E)Failure of septum primum to resorb
Explicação
Failure of neural crest migration into the aorticopulmonary septum is correct. Truncus arteriosus results when the truncal and bulbar ridges fail to form and separate the outflow tract into the aorta and pulmonary artery. This defect is associated with 22q11 d... Ver explicação completa e trilha adaptativa →