A 19-year-old woman with history of recurrent pancreatitis is found to have fasting triglycerides of 650 mg/dL and chylomicrons visible on plasma electrophoresis. Her apoC-II levels are normal, and lipoprotein lipase activity is absent. Genetic testing reveals mutations in the LPL gene. Which of the following pathophysiologic processes is directly impaired in this patient?
- A)Esterification of free fatty acids in adipose tissue
- B)Hepatic synthesis of very low-density lipoprotein
- C)Hepatic uptake of chylomicron remnants
- D)Intestinal synthesis of chylomicrons
- E)Hydrolysis of triglycerides in chylomicrons and VLDL at the capillary endotheliumGABARITO
Explicação
This patient has type I hyperlipoproteinemia (familial chylomicronemia syndrome) caused by lipoprotein lipase (LPL) deficiency. LPL is the key enzyme that hydrolyzes triglycerides in chylomicrons and VLDL at the capillary endothelium of adipose tissue and musc... Ver explicação completa e trilha adaptativa →