A 38 year old man employed in an industrial cleaning facility is accidentally exposed to carbon tetrachloride. Several hours later he develops right upper quadrant pain and elevated aminotransferases. Toxic metabolism generates free radicals that initiate lipid peroxidation of cellular membranes. Which organelle is most directly involved in the formation of this toxic metabolite?
- A)Golgi apparatus
- B)Smooth endoplasmic reticulumGABARITO
- C)Rough endoplasmic reticulum
- D)Lysosome
- E)Nucleolus
Explicação
Carbon tetrachloride is metabolized by cytochrome P450 enzymes in the smooth endoplasmic reticulum to a highly reactive free radical. That radical initiates membrane lipid peroxidation, especially in hepatocytes, causing cell injury and elevated liver enzymes. Ver explicação completa e trilha adaptativa →