A 67-year-old man initiated high-intensity atorvastatin therapy 3 weeks ago following myocardial infarction. He now presents with diffuse myalgias and proximal lower extremity weakness. Vital signs show BP 138/82, HR 88, RR 16, temp 37°C, SpO2 98% on room air. Serum creatine kinase is elevated at 1,200 U/L. Urine myoglobin is negative. Which of the following is the most likely explanation for his presentation?
- A)ALS
- B)Myasthenia gravis
- C)Periodic paralysis
- D)Acute inflammatory demyelinating polyneuropathy
- E)Drug induced toxic myopathyGABARITO
Explicação
Statins can cause a toxic myopathy with myalgias, proximal weakness, and CK elevation. The temporal relation to therapy initiation and lack of sensory findings or fatigability support a medication induced myopathy. Ver explicação completa e trilha adaptativa →