A 58-year-old woman with metastatic lung cancer presents with confusion and nausea. Vital signs show BP 128/76 mmHg, HR 88/min, RR 14/min, temperature 37°C. Serum sodium is 118 mEq/L with normal osmolality and euvolemic examination. Urine osmolality is elevated at 520 mOsm/kg. She denies polyuria. SIADH is diagnosed. Which medication directly antagonizes the renal V2 receptor to raise serum sodium?
- A)TolvaptanGABARITO
- B)Desmopressin
- C)Methimazole
- D)Fludrocortisone
- E)Octreotide
Explicação
Tolvaptan is a V2 receptor antagonist that blocks ADH action at the collecting duct and promotes free water excretion. Ver explicação completa e trilha adaptativa →