A 42-year-old man presents with severe vomiting and diarrhea 6 hours after consuming foraged wild mushrooms. He initially improves but returns 2 days later with jaundice, abdominal pain, and altered mental status. Vitals show BP 98/62, HR 118, RR 22, temp 37.8°C. Laboratory studies reveal INR 4.2, AST 2,400 U/L, and acute kidney injury. Notably, he denies hemoptysis. Which mechanism best explains the responsible toxin's hepatotoxicity?

1. A)Irreversible inhibition of acetylcholinesterase
2. B)Activation of ryanodine receptors
3. C)Blockade of GABA-A receptors
4. D)Inhibition of RNA polymerase IIGABARITO
5. E)Chelation of ferric iron