A 56-year-old man with hypertension presents with BP 168/102 mmHg, HR 88, RR 16, and normal SpO2. He is started on a medication that decreases angiotensin I formation by directly inhibiting the enzyme cleaving angiotensinogen. Serum creatinine is 0.9 mg/dL. He denies chest pain or dyspnea. Previous trials of ACE inhibitors caused persistent cough. Which of the following drugs has this mechanism of action?
- A)Eplerenone
- B)Enalapril
- C)AliskirenGABARITO
- D)Valsartan
- E)Furosemide
Explicação
Aliskiren is a direct renin inhibitor. By blocking renin mediated conversion of angiotensinogen to angiotensin I, it suppresses the renin angiotensin aldosterone system upstream of ACE inhibitors and ARBs. Ver explicação completa e trilha adaptativa →