A term newborn presents with abdominal distension, bilious vomiting, and failure to pass meconium within 48 hours. Vital signs show HR 145 bpm, RR 38/min, temp 37.2°C. Physical examination reveals no anal sphincter tone. Abdominal imaging demonstrates a transition zone in the distal colon with proximal bowel dilation. Rectal biopsy shows congenital absence of enteric ganglia in the aganglionic segment. Failure of migration of which embryologic cell population most likely caused this disorder?
- A)Notochord
- B)Neuroepithelial cells of the neural tube
- C)Paraxial mesoderm
- D)Surface ectoderm
- E)Neural crest cellsGABARITO
Explicação
Neural crest cells is the correct answer because the enteric nervous system, along with dorsal root ganglia, autonomic ganglia, Schwann cells, and adrenal medulla, is derived from neural crest. Failed neural crest migration causes aganglionic bowel in Hirschsp... Ver explicação completa e trilha adaptativa →