A 58-year-old woman with severe rheumatoid arthritis treated with daily oral glucocorticoids for 9 months presents with proximal muscle weakness, thin skin, easy bruising, and hyperglycemia (fasting glucose 165 mg/dL). Physical examination reveals hypertension (BP 158/94 mmHg) and central obesity. DEXA scan demonstrates vertebral compression fractures with T-score of -3.2. She denies fever or recent infections. Which medication is most likely responsible for these findings?
- A)Cinacalcet
- B)HydrocortisoneGABARITO
- C)Finasteride
- D)Levothyroxine
- E)Clomiphene
Explicação
Chronic glucocorticoid exposure causes iatrogenic Cushing syndrome with muscle wasting, skin fragility, hyperglycemia, and osteoporosis. Hydrocortisone is a glucocorticoid and can produce exactly this toxicity pattern when used long term. Ver explicação completa e trilha adaptativa →