A 71-year-old man with Parkinson disease on levodopa/carbidopa for 8 years develops sudden uncontrolled dyskinetic movements of the limbs and trunk for 30 minutes after each dose of medication, alternating with periods of rigidity and bradykinesia. His doses have been escalated progressively. Which of the following best explains this phenomenon?
- A)Medication-induced tardive dyskinesia
- B)Acute stroke involving the basal ganglia
- C)Motor fluctuations and levodopa-induced dyskinesiaGABARITO
- D)Development of Lewy body dementia
- E)Progression of underlying Parkinson disease
Explicação
Long-term levodopa therapy in Parkinson disease causes motor fluctuations (on-off episodes) and levodopa-induced dyskinesia (involuntary choreic movements). This occurs due to pulsatile dopamine receptor stimulation and progressive neurodegeneration, not true ... Ver explicação completa e trilha adaptativa →