A 32-year-old man presents with sudden onset dyspnea, hemoptysis, and hematuria. Chest X-ray shows diffuse alveolar infiltrates. ANCA testing is positive for c-ANCA with anti-PR3 antibodies. Kidney biopsy shows segmental necrotizing GN with crescent formation and sparse immune deposits on immunofluorescence. Which of the following is the most likely diagnosis?
- A)Polyarteritis nodosa
- B)Granulomatous polyangiitis
- C)Granulomatosis with polyangiitis (GPA)GABARITO
- D)Eosinophilic granulomatosis with polyangiitis (EGPA)
- E)Microscopic polyangiitis
Explicação
Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis) is a necrotizing vasculitis affecting small vessels, characterized by c-ANCA/anti-PR3 positivity, pulmonary-renal syndrome with hemoptysis, necrotizing GN with crescents, and necrotizing... Ver explicação completa e trilha adaptativa →