A 69-year-old man with COPD presents with exertional dyspnea and chronic productive cough for the past 8 months. Vital signs show BP 148/92 mmHg, HR 88/min, RR 22/min, SpO2 88% on room air. Spirometry reveals an FEV1/FVC ratio of 0.58. On exam, he has diminished breath sounds bilaterally and a prolonged expiratory phase. He receives inhaled tiotropium, an anticholinergic medication that blocks vagally mediated bronchoconstriction. Chest X-ray shows hyperinflation without acute infiltrates. He denies urinary symptoms. Which of the following adverse effects is most likely with this therapy?
- A)Dry mouthGABARITO
- B)Ototoxicity
- C)Hyperkalemia
- D)Tendon rupture
- E)Pulmonary fibrosis
Explicação
Ipratropium and tiotropium are inhaled antimuscarinic agents that produce bronchodilation by reducing parasympathetic tone in the airways. Because of muscarinic blockade, dry mouth is a common adverse effect. Ver explicação completa e trilha adaptativa →