A 71-year-old woman presents with a 3-year history of progressive memory loss. She repeatedly asks the same questions, frequently misplaces objects, and has become lost while driving in previously familiar neighborhoods. Vital signs are stable (BP 138/82, HR 78, RR 16, Temp 37°C). Mini-Cog score is 2/3. MRI brain shows hippocampal atrophy without focal lesions. Neurologic examination is otherwise normal; gait and tremor are absent. Which neurotransmitter system is most depleted in this disorder?
- A)Dopamine in the substantia nigra
- B)Glycine in the ventral horn
- C)Acetylcholine in the nucleus basalis of MeynertGABARITO
- D)Serotonin in the raphe nuclei
- E)Gamma aminobutyric acid in the caudate
Explicação
Acetylcholine in the nucleus basalis of Meynert is correct. Alzheimer disease features progressive episodic memory impairment with degeneration of cortical and hippocampal neurons, extracellular beta amyloid plaques, and intracellular tau tangles. Loss of chol... Ver explicação completa e trilha adaptativa →