A 32 year old woman undergoes colposcopy after a Pap test shows high grade squamous intraepithelial lesion. Biopsy reveals koilocytosis and dysplastic squamous epithelium. She has a persistent infection with a virus whose proteins inactivate both p53 and retinoblastoma protein. Which of the following is the most likely causal organism?

  1. A)Herpes simplex virus 2
  2. B)Human immunodeficiency virus
  3. C)Varicella zoster virus
  4. D)Epstein Barr virus
  5. E)Human papillomavirus 16GABARITO

Explicação

Human papillomavirus 16 is correct. High risk HPV strains, especially 16 and 18, produce E6 and E7 proteins that inactivate p53 and Rb and promote cervical neoplasia. Koilocytes on histology support HPV infection. Ver explicação completa e trilha adaptativa →

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