A multicenter trial enrolls patients with acute decompensated heart failure in waves of 4 at each site. Within each group of 4, exactly 2 patients are assigned to the new diuretic strategy and 2 to standard care. Which design feature is being used to maintain balance in treatment allocation over time?
- A)Cross over design
- B)Simple randomization
- C)Stratified randomization
- D)Cluster randomization
- E)Block randomizationGABARITO
Explicação
Block randomization assigns participants in small blocks so that treatment groups remain balanced throughout enrollment. In this example, each block of 4 contains a fixed allocation of 2 patients to each arm. This is especially useful in smaller trials or when... Ver explicação completa e trilha adaptativa →