A 31-year-old woman with Graves disease started antithyroid therapy 6 weeks ago. She now presents with fever (38.9°C), severe pharyngitis, and malaise. Vital signs show tachycardia (110 bpm) and tachypnea (20 breaths/min). Laboratory studies reveal WBC 1,200/μL with marked neutropenia; TSH and free T4 are appropriately suppressed. Pregnancy test is negative. She denies recent infections or other medications. Which antithyroid drug most likely caused this adverse effect?
- A)Radioactive iodine
- B)Desmopressin
- C)MethimazoleGABARITO
- D)Levothyroxine
- E)Propranolol
Explicação
Methimazole can cause agranulocytosis, a life threatening complication that often presents with fever and sore throat. In a nonpregnant patient it is commonly chosen over PTU because PTU carries greater hepatotoxic risk. Ver explicação completa e trilha adaptativa →