A 52-year-old woman presents with weight loss and palpitations. Vital signs: BP 142/88, HR 108, RR 18, Temp 37.2°C, SpO2 98%. Laboratory studies show elevated free T4 (28 pg/mL) and suppressed TSH (0.01 mIU/L); thyroid ultrasound reveals a 1.2-cm hypoechoic nodule. A hospital designs a two-step screening program for thyroid cancer. The first test should miss as few true cases as possible, whereas the second will confirm disease among screen-positive patients. Which test combination is most appropriate?
- A)First test with high specificity, second test with high sensitivity
- B)First test with low negative predictive value, second test with low positive predictive value
- C)Both tests with low sensitivity
- D)Both tests with low specificity
- E)First test with high sensitivity, second test with high specificityGABARITO
Explicação
The initial screening test should have high sensitivity so that few diseased patients are missed. The confirmatory test should then have high specificity to reduce false positives and rule in disease among those who screened positive. This is the standard Step... Ver explicação completa e trilha adaptativa →