A 63-year-old man with type 2 diabetes presents with fatigue and polyuria. Vital signs show BP 142/88 mmHg, HR 88/min, RR 16/min, temperature 37.2°C, and SpO2 98% on room air. His fasting glucose is 185 mg/dL with HbA1c of 8.2%. He denies recent weight loss or infections. His physician initiates therapy with a medication that increases insulin secretion by closing ATP-sensitive potassium channels in pancreatic beta cells. Which drug most likely has this mechanism of action?

  1. A)Metformin
  2. B)GlipizideGABARITO
  3. C)Acarbose
  4. D)Empagliflozin
  5. E)Pioglitazone

Explicação

Sulfonylureas such as glipizide stimulate insulin secretion by binding the SUR1 subunit of ATP sensitive potassium channels on beta cells. Ver explicação completa e trilha adaptativa →

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