A 63-year-old man with type 2 diabetes presents with fatigue and polyuria. Vital signs show BP 142/88 mmHg, HR 88/min, RR 16/min, temperature 37.2°C, and SpO2 98% on room air. His fasting glucose is 185 mg/dL with HbA1c of 8.2%. He denies recent weight loss or infections. His physician initiates therapy with a medication that increases insulin secretion by closing ATP-sensitive potassium channels in pancreatic beta cells. Which drug most likely has this mechanism of action?
- A)Metformin
- B)GlipizideGABARITO
- C)Acarbose
- D)Empagliflozin
- E)Pioglitazone
Explicação
Sulfonylureas such as glipizide stimulate insulin secretion by binding the SUR1 subunit of ATP sensitive potassium channels on beta cells. Ver explicação completa e trilha adaptativa →