A 55-year-old woman presents with progressive weight loss and a 3-month history of a recurrent erythematous, vesicular rash affecting the groin and perioral regions. Vital signs show BP 128/82 mmHg, HR 92/min, RR 16/min, temperature 37.2°C, and SpO2 98% on room air. Fasting glucose is 156 mg/dL. Examination confirms necrolytic migratory erythema with central erosions. She denies diarrhea. Which of the following tumors most likely explains her clinical presentation?
- A)Insulinoma
- B)Somatostatinoma
- C)VIPoma
- D)GlucagonomaGABARITO
- E)Gastrinoma
Explicação
Glucagonomas are pancreatic alpha cell tumors that cause diabetes, weight loss, and necrolytic migratory erythema. The rash is a highly tested clue. Glucagon excess increases hepatic glucose production and contributes to hyperglycemia. Ver explicação completa e trilha adaptativa →