A 17 year old boy is evaluated for recurrent sinusitis and chronic watery diarrhea. He has had two prior episodes of Giardia lamblia infection. He is otherwise healthy. Serum immunoglobulin studies show markedly decreased IgA with normal IgG and IgM. Which of the following additional complications is this patient most at risk for?
- A)Chronic mucocutaneous candidiasis due to AIRE mutation
- B)Aplastic crisis after parvovirus B19 infection
- C)Neisseria meningitidis sepsis due to terminal complement deficiency
- D)Recurrent staphylococcal abscesses due to neutrophil oxidative burst failure
- E)Anaphylaxis after blood transfusionGABARITO
Explicação
Selective IgA deficiency predisposes to mucosal infections, Giardia, and anaphylactic reactions to blood products that contain donor IgA. Patients can form anti IgA antibodies, so transfusion exposure may trigger severe immediate hypersensitivity. Ver explicação completa e trilha adaptativa →