A 24 year old Southeast Asian woman is noted to have persistent microcytosis on routine laboratory testing during pregnancy. She feels well and denies bleeding. Hemoglobin is 11.6 g/dL and MCV is 71 fL. Ferritin is normal. Peripheral smear shows target cells. Hemoglobin electrophoresis is normal. Which of the following is the most likely diagnosis?
- A)Beta thalassemia major due to absent beta globin synthesis
- B)Iron deficiency anemia due to pregnancy
- C)Hereditary spherocytosis due to ankyrin defect
- D)Alpha thalassemia trait due to deletion of 2 alpha globin genesGABARITO
- E)Sideroblastic anemia due to pyridoxine deficiency
Explicação
Alpha thalassemia trait due to deletion of 2 alpha globin genes is correct. Alpha thalassemia trait causes mild microcytosis with normal iron studies and often a normal hemoglobin electrophoresis because all hemoglobin types contain alpha chains. The diagnosis... Ver explicação completa e trilha adaptativa →