A 68-year-old man with hypertension and angina presents with dizziness and fatigue. Vital signs show BP 92/58 mmHg, HR 48 bpm, RR 14/min, temp 37°C, SpO2 98% on room air. He reports taking metoprolol 100 mg daily for 2 years. Electrocardiogram reveals normal sinus rhythm without conduction delays. He denies syncope. Which of the following best explains how beta-blockers' decreased blood solubility affects drug distribution and clinical onset of action?
- A)Hepatic metabolism becomes the dominant determinant of recovery
- B)Potency always increases as blood solubility decreases
- C)The minimum alveolar concentration necessarily increases with blood solubility
- D)More drug is retained in blood, delaying equilibration with the brain
- E)The alveolar partial pressure rises quickly, accelerating inductionGABARITO
Explicação
Inhaled anesthetics with low blood solubility equilibrate less with blood and more rapidly build alveolar partial pressure. This allows faster equilibration with the brain, leading to rapid induction and rapid recovery when the anesthetic is discontinued. Ver explicação completa e trilha adaptativa →